01618nas a2200385 4500000000100000008004100001260001300042653001500055653001000070653002100080653001900101653003000120653001100150653001100161653001400172653001000186653002300196653001200219653000900231653001600240653002500256653002200281653002400303653002100327100001400348700001300362700001400375700001200389245006800401856004100469300001000510490000700520520069100527022001401218 1998 d c1998 Dec10aAdolescent10aAdult10aAge Distribution10aCohort Studies10aDrug Therapy, Combination10aFemale10aHumans10aIncidence10aIndia10aLeprostatic Agents10aleprosy10aMale10aMiddle Aged10aMycobacterium leprae10aPeripheral nerves10aProspective Studies10aSex Distribution1 aSolomon S1 aKurian N1 aRamadas P1 aRao P S00aIncidence of nerve damage in leprosy patients treated with MDT. uhttp://ila.ilsl.br/pdfs/v66n4a02.pdf a451-60 v663 a

The incidence rates of sensory and motor impairments during and after multidrug therapy (MDT) are reported for a prospective cohort of patients who had no nerve damage at registration (N = 1621). Sensory and motor loss increased with age and both were high among multibacillary patients as compared with paucibacillary patients. The lateral popliteal (common peroneal) and posterior tibial nerves seem to be most affected for sensory loss; whereas the posterior tibial and ulnar nerves are mainly responsible for motor loss. No significant difference by gender was found. Implications for prevention of disability (POD) activities are discussed and suitable recommendations made.

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