01222nas a2200205   4500000000100000008004100001260001300042653001100055653002400066653001200090653001600102653002500118653001400143100002000157245010000177300001100277490000600288520070800294022001401002       1983                            d  c1983 Dec10aHumans10aIn Vitro Techniques10aleprosy10aMacrophages10aMycobacterium leprae10aPhenotype1 aFreire-Maia D V00a[Familial analysis of the in vitro behavior of human macrophages against Mycobacterium leprae].  a91-1000 v83 a<p>The lysogenic capacity of human macrophages facing M. leprae in vitro may be dependent on an important genetic component. Although the family aggregation of the trait is demonstrated, this is a necessary but not sufficient condition to prove genetic influence. The data do not fit some simple genetic models (autosomal dominant or incompletely dominant gene; dominant or recessive sex-linked gene). The results obtained are consistent with the hypothesis that the macrophages' lysogenic capacity is mainly due to a major gene with variable expressivity. This hypothesis may be too simple to account for the whole variability detected and therefore must be considered just as a working hypothesis.</p>  a0100-3283