01555nas a2200277   4500000000100000008004100001260001300042653001000055653001200065653003100077653002000108653001100128653001100139653001800150653001200168653000900180653002100189100001300210700001400223700001400237245011300251300001000364490000800374520088100382022001401263       1984                            d  c1984 Jan10aAdult10aDapsone10aDrug Resistance, Microbial10aEyelid Diseases10aFemale10aHumans10aIris Diseases10aleprosy10aMale10aTissue Adhesions1 aBrandt F1 aAdiga R B1 aPradhan H00a[Lagophthalmos and posterior synechiae of the iris during treatment of leprosy with diaminodiphenylsulfone].  a28-310 v1843 a<p>Four years after controlled and standardized chemotherapy with diaminodiphenylsulfone (DDS), 316 patients in the leprosarium at Khokana, Nepal were re-examined for ophthalmological findings. Patients who, 4 years earlier, had not had lagophthalmos in either eye, nor posterior synechiae of the iris, had only developed these complications in the meantime if they were suffering from DDS-resistant leprosy. New posterior synechiae of the iris were only found in patients with inactive leprosy who had already had a posterior synechia in the fellow eye four years previously. In cases of inactive leprosy there was also a tendency for existing posterior synechiae to increase. It is emphasized that the development of lagophthalmos or posterior synechiae of the iris indicates that a previously inactive leprosy may have become reactivated in spite of treatment with DDS.</p>  a0023-2165