01273nas a2200325   4500000000100000008004100001260001300042653001500055653001000070653001600080653000900096653001000105653002100115653001100136653001100147653001100158653001200169653000900181653001600190653002800206653001400234653001800248100001700266700001500283245001300298300001000311490000700321520060500328022001400933       1982                            d  c1982 Nov10aAdolescent10aAdult10aAge Factors10aAged10aChild10aChild, Preschool10aFemale10aHumans10aInfant10aleprosy10aMale10aMiddle Aged10aNervous System Diseases10aSensation10aSkin Diseases1 aHendrick S S1 aWilkin J K00aLeprosy.  a161-60 v263 a<p>The incidence of Hansen's disease is increasing in the United States. Early diagnosis can prevent irreparable damage. Sensory changes are often the first manifestations of tuberculous leprosy. In the lepromatous form, a variety of skin lesions pose diagnostic puzzles. The definitive diagnosis is made by histopathologic examination of skin or mucosa. Multidrug therapy, specifically dapsone and rifampin, is recommended for all newly diagnosed leprosy patients. In cases of untreated borderline or lepromatous leprosy, dapsone prophylaxis is advised for family contacts under 25 years of age.</p>  a0002-838X