01425nas a2200301   4500000000100000008004100001260000900042653001600051653001100067653001100078653002100089653001600110653002300126653001400149653002500163653001600188653001800204100001200222700001500234700001300249700001400262700001100276245009300287300001100380490000600391520071200397022001401109       1982                            d  c198210aClofazimine10aFemale10aHumans10aJejunal Diseases10aLymph Nodes10aLymphatic Diseases10aMesentery10aMicroscopy, Electron10aMiddle Aged10aSkin Diseases1 aMicco C1 aBoutboul R1 aDevaux J1 aCharpin C1 aToga M00a[Enteropathy due to clofazimine treatment. A case report with an ultrastructural study].  a149-540 v23 a<p>The authors report a case of enteropathy due to clofazimine treatment for prurigo nodularis. The drug usually restricted to the treatment of leprosy has sometime been given to patients suffering from skin diseases because of its assumed anti-inflammatory effects. When high dosage of clofazimine treatment is carried on during a long period, and drug accumulates in the tissues and precipitates as a solid. This crystal storage in the lamina propria of the jejunal mucosa and in the mesenteric lymph nodes accounts for an enteropathy, sometime severe but slowly regressing after drug withdrawal. The electron microscopic study shows the prints of these crystals in autophagic vacuoles of histiocytes.</p>  a0242-6498