02101nas a2200433 4500000000100000008004100001260001700042653001500059653001000074653000900084653001100093653001000104653002100114653002600135653001100161653004400172653001100216653001100227653002000238653000900258653001600267653002600283653002600309653002200335653001600357100001500373700001500388700001600403700001300419700001500432700001300447700001300460700001700473245014200490300001100632490000700643520100300650022001401653 2009 d c2009 Oct-Dec10aAdolescent10aAdult10aAged10aBrazil10aChild10aChild, Preschool10aCommunicable Diseases10aFemale10aHematopoietic Stem Cell Transplantation10aHumans10aInfant10aInfant, Newborn10aMale10aMiddle Aged10aOrgan Transplantation10aRetrospective Studies10aTropical Medicine10aYoung Adult1 aMachado CM1 aMartins TC1 aColturato I1 aLeite MS1 aSimione AJ1 aSouza MP1 aMauad MA1 aColturato VR00aEpidemiology of neglected tropical diseases in transplant recipients. Review of the literature and experience of a Brazilian HSCT center. a309-240 v513 a

The rising success rate of solid organ (SOT) and haematopoietic stem cell transplantation (HSCT) and modern immunosuppression make transplants the first therapeutic option for many diseases affecting a considerable number of people worldwide. Consequently, developing countries have also grown their transplant programs and have started to face the impact of neglected tropical diseases (NTDs) in transplant recipients. We reviewed the literature data on the epidemiology of NTDs with greatest disease burden, which have affected transplant recipients in developing countries or may represent a threat to transplant recipients living in other regions. Tuberculosis, Leprosy, Chagas disease, Malaria, Leishmaniasis, Dengue, Yellow fever and Measles are the topics included in this review. In addition, we retrospectively revised the experience concerning the management of NTDs at the HSCT program of Amaral Carvalho Foundation, a public transplant program of the state of São Paulo, Brazil.

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