01823nas a2200325   4500000000100000008004100001260001700042653001600059653001800075653001100093653002100104653002100125653002100146653003200167653003300199653002100232653002000253653001200273653001900285653002300304653001600327100002000343700001100363245011800374856004100492300001100533490000700544520093200551022001401483       1976                            d  c1976 Oct-Dec10aAlbuminuria10aComplement C310aHumans10aImmunoglobulin A10aImmunoglobulin D10aImmunoglobulin G10aImmunoglobulin kappa-Chains10aImmunoglobulin lambda-Chains10aImmunoglobulin M10aImmunoglobulins10aleprosy10aMacroglobulins10aNephrotic Syndrome10aTransferrin1 aChakraborty A K1 aSaha K00aImmunologic aspects of leprosy with reference to extravascular immunoglobulins: their excretion profile in urine.  uhttp://ila.ilsl.br/pdfs/v44n4a07.pdf  a456-610 v443 a<p>An aliquot of 24-hour urine collected from leprosy patients was concentrated and examined for the presence of albumin, transferrin, IgG, IgA, IgM, IgD, D3, kappa and lambda light chains by the gel diffusion technic using respective monospecific antisera. Urinary protein excretion profile in lepromatous leprosy patients showed that while excretion of transferrin in the urine was negligible; that of IgG molecules, a substance of higher molecular weight, was significant. It is suggested that the immunoglobulins excreted in the urine may not be plasma-derived, but extravascular in origin. They are probably synthesized in the urinary tract. In the present study, out of 25 leprosy patients, 2 female patients having severe lepra reactions developed urinary tract infections. E. coli and Klebsiella were isolated from their urine. The urinary IgG levels in those two cases were found to be the highest in the series.</p>
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