02255nas a2200313   4500000000100000008004100001260001300042653001500055653001000070653001100080653001100091653001200102653000900114653001600123653002200139653000900161100001100170700001500181700001200196700001100208700001600219245009800235856005900333300001000392490000700402050003200409520148600441022001401927       1993                            d  c1993 Jun10aAdolescent10aAdult10aFemale10aHumans10aleprosy10aMale10aMiddle Aged10aPeripheral nerves10aSkin1 aKaur S1 aSharma V K1 aBasak P1 aKaur I1 aRadotra B D00aConcurrent skin and nerve histology in leprosy and its role in the classification of leprosy.  uhttp://leprev.ilsl.br/pdfs/1993/v64n2/pdf/v64n2a04.pdf  a110-60 v64  aInfolep Library - available3 a<p>Concurrent skin and nerve histology was evaluated in 60 leprosy patients (25 BT, 28 BL and 7 LL). The twin aims were to study the comparative histology and the usefulness of nerve histology in the classification of the disease. In BT patients, clinical and histological classification was in agreement in 11 (44%) skin and 17 (68%) nerve biopsies. Concurrent skin and nerve histology was in consonance in 14 (56%) BT patients, while in 6 (24%) patients, only nerve histology was helpful in the classification of the disease, the skin histology being non-specific. Nerve histology was classified as BL in 3 (12%) BT patients, the skin histology was non-specific. In the BL group, the histology of 23 (82.4%) nerve biopsies correlated with the clinical classification, in contrast to skin histology which correlated with clinical assessment in 19 (68%) patients only. In the LL patients, the histology of nerve correlated with the clinical classification in 5 patients (71.4%), compared to histology of the skin in 4 (57%) patients only. The GF was higher in the nerves than in the skin throughout the leprosy spectrum (BT, BL, LL); the difference was, however, marginal in BL leprosy. The average bacteriological index (BI) was higher in nerves (4+) compared to that of skin histology and slit skin smears (3+) in BL leprosy. There was, however, no difference in the BI of the slit skin smears, skin and nerve biopsies in lepromatous leprosy.(ABSTRACT TRUNCATED AT 250 WORDS)</p>  a0305-7518