01193nas a2200193   4500000000100000008004100001260001300042653001200055653001200067653000900079653002000088100001500108700001800123245005400141300001000195490000800205520077200213022001400985       1977                            d  c1977 Jul10aAnimals10aleprosy10aMale10aPan troglodytes1 aDonham K J1 aLeininger J R00aSpontaneous leprosy-like disease in a chimpanzee.  a132-60 v1363 a<p>The clinical and laboratory findings of a spontaneous disease, resembling human leprosy, in a chimpanzee are described. The disease was a chronic progressive dermatitis characterized by nodular thickenings of the dermis and involving the  ears, eyebrows, nostrils, and lips. A maculopapular rash was also present. Numerous acid-fast organisms were found in nasal swabs and in dermal lesions, including nerves. Attempts to culture acid-fast organisms in artificial media have failed. At this time, the only features of the etiologic agent of this disease that are inconsistent with those of Mycobacterium leprae are failure of the organisms to oxidize 3, 4-dihydroxyphenylalanine and failure to pyridine to remove the acid-fast staining property of the bacilli.</p>  a0022-1899