01639nas a2200265   4500000000100000008004100001260001300042653003900055653000900094653002900103653003600132653001800168653001500186653001100201653001200212653001600224653001900240653001700259100001700276245010900293300001000402490000700412520094000419022001401359       1996                            d  c1996 Aug10aAfrican Continental Ancestry Group10aAged10aCarcinoma, Squamous Cell10aCell Transformation, Neoplastic10aFoot Diseases10aFoot Ulcer10aHumans10aleprosy10aMiddle Aged10aSkin Neoplasms10aSouth Africa1 aSchoeman B J00a[Squamous cell carcinoma in neuropathic plantar ulcers in leprosy: another example of Marjolin's ulcer].  a966-90 v863 a<p>Seven cases of squamous cell carcinoma (SCC) arising in chronic neuropathic plantar ulcers of leprosy are described. These patients (average age 59 years) presented over a 5-year period. The mean duration of neuropathic ulceration until diagnosis of SCC was 24.5 years. Six patients required limb amputations and 3 underwent lymphadenectomy for involved nodes. One patient died of disseminated disease. The history of the eponym "Marjolin's ulcer' is traced and a case put forward for recognition of malignant change in neuropathic ulcers as yet another example of Marjolin's ulcer. A plea is made for an increased awareness of the possibility of malignant transformation in chronic neuropathic ulcers in order to effect an early diagnosis of a potentially aggressive cancer. This is the first report of its kind in South Africa. Similar cases, however, have been reported from other parts of the world where leprosy is endemic.</p>  a0256-9574