02096nas a2200301   4500000000100000008004100001260000900042653001500051653001000066653004200076653002500118653001100143653002300154653002300177653001100200653001200211653000900223100001100232700001200243700001200255700001300267700001200280245008500292300000900377490000700386520138700393022001401780       1996                            d  c199610aAdolescent10aAdult10aAIDS-Related Opportunistic Infections10aCase-Control Studies10aFemale10aHIV Seronegativity10aHIV Seropositivity10aHumans10aleprosy10aMale1 aFaye O1 aMahé A1 aJamet P1 aHuerre M1 aBobin P00a[Anatomopathologic study of five cases of leprosy in HIV seropositive patients].  a93-90 v103 a<p>In an effort to establish whether the human immunodeficiency virus (HIV) modifies the histological image of lepromatous skin lesion, a comparative study was conducted in 1994 at the Marchoux Institute in Bamako, Mali, on persons newly suffering from leprosy who had been tested seropositive and seronegative for the HIV virus. These new leprosy patients had never been treated and could be grouped as follows: 5 HIV-positive (1 TT, 1 BT, 1 BL, 2 LL) and 10 controls testing HIV-negative, selected according to the following criteria: each seropositive leprosy subject was matched with two seronegative controls having the same clinical features, same stage under the Ridley classification system, same age and sex. No discordance between the clinical classifications and the histological features in the subjects testing HIV-positive has been observed. They display features similar to those testing negative, with the presence of histiocytes, in particular epithelioid cells and giant cells in normal proportion depending on the form of leprosy. The only remarkable difference was a greater incidence of oedema in the subjects testing seropositive, compared with patients testing seronegative. In conclusion, HIV infection does not appear to cause major modifications in cellular response to Mycobacterium leprae, and no changes should be made in leprosy control programmes.</p>  a0001-5938