02051nas a2200469   4500000000100000008004100001260000900042653001200051653001200063653002600075653002500101653002100126653003000147653002200177653002700199653002000226653003800246653002200284653001800306653002200324653001800346653001100364653002100375653001800396653002300414653001200437653001600449653002200465653000900487653002500496653003100521653002600552653001700578100001400595700001300609700001100622245010500633300001100738490000700749520081100756022001401567       1998                            d  c199810aAlleles10aAnimals10aAntitubercular Agents10aBacterial Infections10aCarrier Proteins10aCation Transport Proteins10aDisease Outbreaks10aDisease Susceptibility10aGenetic Linkage10aGenetic Predisposition to Disease10aGenome, Bacterial10aGenome, Human10aGenome, Protozoan10aGlobal health10aHumans10aImmunity, Innate10aLeishmaniasis10aLeprostatic Agents10aleprosy10aMacrophages10aMembrane Proteins10aMice10aMycobacterium leprae10aMycobacterium tuberculosis10aSalmonella Infections10aTuberculosis1 aSkamene E1 aSchurr E1 aGros P00aInfection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections.  a275-870 v493 a<p>The scope of the tuberculosis (TB) epidemic in the world today is enormous, with about 30 million active cases. Current research into preventing the spread of TB is focused on development of new drugs to inactivate Mycobacterium tuberculosis, the causative agent of TB, as well as on identifying the critical steps of host defense to infection with Mycobacteria, which might also yield therapeutic targets. Our infection genomics approach toward the latter strategy has been to isolate and characterize a mouse gene, Bcg (Nramp1), which controls natural susceptibility to infection with Mycobacteria, as well as Salmonella and Leishmania. Through comparative genomics, we have identified the homologous human NRAMP1 gene, alleles of which are now being used for tests of linkage with TB and leprosy.</p>  a0066-4219