01461nas a2200265   4500000000100000008004100001260001700042653001200059653003100071653001100102653001200113653000900125653002500134653003100159653001500190653001700205100001400222700001500236245007700251300001100328490000700339050003200346520080300378022001401181       1997                            d  c1997 Oct-Dec10aAnimals10aDrug Resistance, Microbial10aHumans10aleprosy10aMice10aMycobacterium leprae10aMycobacterium tuberculosis10aRecurrence10aTuberculosis1 aGupta U D1 aKatoch V M00aUnderstanding the phenomenon of persistence in mycobacterial infections.  a385-930 v69  aInfolep Library - available3 a<p>Persistence of live organisms despite chemotherapy for long periods is a significant problem in both leprosy and tuberculosis. The consequence of this persistence is varying rates of relapses which undermine the success of treatment. The mechanisms of the dormancy are ill-understood, and as explanation a switch over to alternate modes of metabolism such as glyoxylate bypass and other shunts has been suggested. This presentation reviews the information available on this aspect. In-depth studies by designing and investigating model system(s) using molecular genetic approaches may help in gaining better understanding of the mechanisms of dormancy and persistence in mycobacterial infections and devising appropriate strategies and tools for the better management of these complications.</p>  a0254-9395