02265nas a2200457   4500000000100000008004100001260001300042653001500055653001000070653000900080653002600089653003700115653002100152653001100173653001100184653002100195653002100216653002100237653002300258653002400281653002500305653002500330653000900355653001600364653002500380653001600405653003200421100002200453700002200475700002200497700001900519700001200538700002000550700002100570245013800591856014700729300000900876490000800885520090000893022001401793       1998                            d  c1998 May10aAdolescent10aAdult10aAged10aAntibodies, Bacterial10aData Interpretation, Statistical10aErythema Nodosum10aFemale10aHumans10aImmunoglobulin G10aImmunoglobulin M10aInterferon-gamma10aLeprostatic Agents10aLeprosy, Borderline10aLeprosy, lepromatous10aLeprosy, Tuberculoid10aMale10aMiddle Aged10aMycobacterium leprae10aThalidomide10aTumor Necrosis Factor-alpha1 aPartida-Sanchez S1 aFavila-Castillo L1 aPedraza-Sanchez S1 aGomez-Melgar M1 aSaúl A1 aEstrada-Parra S1 aEstrada-Garcia I00aIgG antibody subclasses, tumor necrosis factor and IFN-gamma levels in patients with type II lepra reaction on thalidomide treatment.  uhttp://academia.edu/2039784/lgG_subclasses_antibodies_TNF_IFN-gamma_levels_in_patients_with_type-II_lepra_reaction_under_thalidomide_treatment  a60-60 v1163 a<p>A group of 9 Mexican lepromatous leprosy patients was studied at the beginning of a type II reaction (erythema nodosum leprosum, ENL) and after 1 or 2 months of thalidomide treatment. ENL patients at the onset of the reaction had slightly higher amounts of anti-Mycobacterium leprae IgG1 and IgG2 antibodies, compared to similar lepromatous patients that did not develop ENL. Neither these antibody levels nor IgM and the other IgG subclasses were importantly modified after thalidomide treatment. Serum TNF was significantly higher in the patients that developed ENL compared to those that did not develop the reaction. TNF levels were slightly decreased after 1 month of thalidomide treatment and significantly decreased after 2 months of treatment. Serum IFN-gamma was significantly lower in patients at the onset of ENL and was increased after 1 and 2 months of thalidomide treatment.</p>  a1018-2438