01750nas a2200385   4500000000100000008004100001260000900042653002300051653002300074653001800097653002500115653003100140653001100171653002700182653003700209653001200246653001600258653002500274653001300299653002300312653001400335653001700349653003100366653001300397653001800410653001700428100002100445700001200466700001300478245007700491300000900568490000700577520076600584022001401350       1975                            d  c197510aAgammaglobulinemia10aAntibody Formation10aB-Lymphocytes10aCell Differentiation10aComplement System Proteins10aHumans10aHypergammaglobulinemia10aImmunologic Deficiency Syndromes10aleprosy10aLymph Nodes10aLymphocyte Depletion10aLymphoma10aParathyroid Glands10aPhenotype10aPlasma Cells10aReceptors, Antigen, B-Cell10aSyndrome10aT-Lymphocytes10aThymus Gland1 aGajl-Peczalska K1 aLim S D1 aGood R A00aB lymphocytes in primary and secondary deficiencies of humoral immunity.  a33-50 v113 a<p>The quantitative studies of B lymphocytes in peripheral blood have been performed in various forms of primary and secondary immunodeficiency disease in man. X-linked agammaglobulinemia was found to comprise two sub-types, one lacking B-cell population, the other showing low numbers of B lymphocytes. The absence of B cells in severe combined immunodeficiency was corrected by marrow transplants in 3 children. Cases of DiGeorge syndrome and lepromatous leprosy showed an absolute increase in numbers of B lymphocytes in peripheral blood, probably a compensatory mechanism in the market deficit of T-cell population and function. The reconstitution of DiGeorge syndrome by fetal thymus transplant reversed the abnormally high percentage of B lymphocytes.</p>  a0547-6844