01869nas a2200265 4500000000100000008004100001260001300042653003900055653003600094653002500130653002200155653001100177653002300188100001400211700001500225700001300240700001400253700002600267245007300293856005300366300001100419490000700430520115200437022001401589 2010 d c2010 Dec10aAcquired Immunodeficiency Syndrome10aCommunicable Diseases, Emerging10aDeveloping countries10aHealth Transition10aHumans10aNeglected Diseases1 aPonte CMM1 aGurgel MHC1 aPonte GA1 aRamos AVA1 aMontenegro JĂșnior RM00a[Metabolic disorders in emerging and neglected infectious diseases]. uhttp://www.scielo.br/pdf/abem/v54n9/a03v54n9.pdf a785-920 v543 a
The gradual and progressive replacement of infectious and parasitic by chronic diseases as causes of morbidity and mortality, characterizing the process of epidemiological transition hasn't been observed in various populations, especially in underdeveloped or developing countries characterizing a superposition of these profiles (incomplete transition). Besides the increased prevalence of metabolic disorders, various infectious diseases remain endemic in several regions, such as leprosy, tuberculosis, leishmaniasis, viral hepatitis, among others, as well as emerging diseases in recent decades, as HIV infection/Aids. In this context, more attention has been given to the occurrence of metabolic disturbances in the recent years, mainly from the observation of a high incidence of metabolic disorders associated with HIV infection/Aids, and its therapy with antiretroviral drugs. This review addresses clinical and epidemiological aspects of metabolic disturbances reported in some infectious and parasitic diseases with worldwide and local (Brazil) relevance, as well as possible mechanisms and factors involved in these associations.
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