02416nas a2200385   4500000000100000008004100001260001300042653001500055653001000070653001000080653003300090653001100123653002200134653001100156653001400167653002300181653001200204653000900216653001600225653001400241653002600255653001300281653001700294653002200311100001500333700001500348700001600363245012500379856005900504300002800563490001300591050003200604520138000636022001402016       2000                            d  c2000 Dec10aAdolescent10aAdult10aChild10aDrug Administration Schedule10aFemale10aFollow-Up Studies10aHumans10aIncidence10aLeprostatic Agents10aleprosy10aMale10aMiddle Aged10aPolynesia10aRetrospective Studies10aRifampin10aRisk Factors10aTreatment Outcome1 aNguyen L N1 aCartel J L1 aGrosset J H00aChemoprophylaxis of leprosy in the southern Marquesas with a single 25 mg/kg dose of rifampicin. Results after 10 years.  uhttp://leprev.ilsl.br/pdfs/2000/v71s1/pdf/v71s1a07.pdf  aS33-5; discussion S35-60 v71 Suppl  aInfolep Library - available3 a<p>In 1988, a programme of leprosy chemoprophylaxis, employing a supervised, single 25 mg/kg dose of rifampicin, was implemented in the Southern Marquesas Islands. Of the 2786 inhabitants, 2751 (98.7%) were treated. In addition, 3144 South Marquesans living elsewhere in French Polynesia were administered the same chemoprophylaxis. During the following 10 years, seven leprosy patients were detected among those who had been administered chemoprophylaxis. Of these, two were very likely missed cases of leprosy, and cannot be considered a failure of chemoprophylaxis. The epidemiometric projection model, based on cases of leprosy observed in the Southern Marquesas during the 20 years preceding implementation of the programme, predicted that 17 leprosy cases could be expected in the South Marquesan population if no chemoprophylaxis were given. In fact, only five cases were detected in the treated population, a number significantly smaller than 17, suggesting that the chemoprophylaxis was 70% effective, assuming that no change of detection rate would have occurred without chemoprophylaxis. However, during the 10 years following implementation of the chemoprophylaxis programme, the detection rate in the Polynesian population that was not administered chemoprophylaxis declined by about 50%. Therefore, the effectiveness of the chemoprophylaxis was only 35-40%.</p>  a0305-7518