01501nas a2200253   4500000000100000008004100001260001300042653001100055653001200066653002500078100001200103700001200115700002000127700001500147700001700162700001800179245006500197856004100262300001000303490000700313050001500320520089800335022001401233       2001                            d  c2001 Mar10aHumans10aleprosy10aMycobacterium leprae1 aNaafs B1 aSilva E1 aVilani-Moreno F1 aMarcos E C1 aNogueira M E1 aOpromolla D V00aFactors influencing the development of leprosy: an overview.  uhttp://ila.ilsl.br/pdfs/v69n1a04.pdf  a26-330 v69  aNAAFS 20013 a<p>The clinical manifestations of leprosy vary, seemingly depending on the host's immune response. Mode and route of infection, such as skin versus nasal mucosa, insect bites, sexual and gastroenteral transmission, together with genetic factors that may contribute to the outcome of the infection, including HLA, Lewis factor, Nramp1 and more subtle inherited alterations, are discussed. It is theorized that a balance between host responses elicited by different routes of infection and size and spacing of inocula is responsible for the clinical and immunological manifestations of the disease. Genetic factors and contact with environmental microorganisms may modulate these responses. The final result, resistance, delayed-type hypersensitivity, tolerance, disease or no disease, spectrum and reactions, is most likely reached via the orchestration of the induced cyto- and chemokines.</p>  a0148-916X