01535nas a2200301   4500000000100000008004100001260001300042653002400055653002600079653002300105653001800128653002600146653004200172653001100214653002800225653001800253653003100271653003400302653001700336100001100353700001100364700001000375245006700385300001100452490000700463520074900470022001401219       2013                            d  c2013 Mar10aAmino Acid Sequence10aAntitubercular Agents10aBacterial Proteins10aCell Division10aCytoskeletal Proteins10aGene Expression Regulation, Bacterial10aHumans10aMolecular Sequence Data10aMycobacterium10aMycobacterium tuberculosis10aSequence Homology, Amino Acid10aTuberculosis1 aHong W1 aDeng W1 aXie J00aThe structure, function, and regulation of Mycobacterium FtsZ.  a97-1050 v653 a<p>FtsZ is a widely distributed major cytoskeletal protein involved in the archaea and bacteria cell division. It is the most critical component in the division machinery and similar to tubulin in structure and function. Four major roles of FtsZ have been characterized: cell elongation, GTPase, cell division, and bacterial cytoskeleton. FtsZ subunits can be assembled into protofilaments. Mycobacteria consist of a large family of medical and environmental important bacteria, such as M. leprae, M. tuberculosis, the pathogen of leprosy, and tuberculosis. Structure, function, and regulation of mycobacteria FtsZ are summarized here, together with the implication of FtsZ as potential novel drug target for anti-tuberculosis therapeutics.</p>  a1559-0283