01683nas a2200325   4500000000100000008004100001653002200042653001500064653001200079653001400091100001500105700001700120700001400137700001300151700001800164700001400182700001400196700001600210700001200226700002800238700001600266700001500282700001600297700002600313245004700339856006700386490000700453050001700460520088000477       2013                            d10aSystematic review10aNeuropathy10aleprosy10adiagnosis1 aGarbino JA1 aMarques Jr W1 aBarreto J1 aHeise CO1 aRodrigues MMJ1 aAntunes S1 aSoares CT1 aFloriano MC1 aNery JA1 aBianconcini Trindade MA1 aCarvalho NB1 aAndrada NC1 aBarreira AA1 aCunha Lopes Virmond M00aPrimary neural leprosy : systematic review  uhttp://www.scielo.br/pdf/anp/v71n6/0004-282X-anp-71-06-397.pdf0 v71  aGARBINO 20133 a<p>The authors proposed a systematic review on the current concepts of primary neural leprosy by consulting the following online databases: MEDLINE, Lilacs/SciELO, and Embase. Selected studies were classified based on the degree of recommendation and levels of scientific evidence according to the “Oxford Centre for Evidence-based Medicine”. The following aspects were reviewed: cutaneous clinical and laboratorial investigations, i.e. skin clinical exam, smears, and biopsy, and Mitsuda's reaction; neurological investigation (anamnesis, electromyography and nerve biopsy); serological investigation and molecular testing, i.e. serological testing for the detection of the phenolic glycolipid 1 (PGL-I) and the polymerase chain reaction (PCR); and treatment (classification criteria for the definition of specific treatment, steroid treatment, and cure criteria).</p>