01160nas a2200301   4500000000100000008004100001260001300042653002200055653002600077653002600103653002600129653002600155653002600181653002100207653002200228653001100250653001200261653001700273653002500290653003100315653001700346100001500363245007100378300001100449490000700460520037700467022001400844       2013                            d  c2013 Sep10aGenome, Bacterial10aHistory, 15th Century10aHistory, 16th Century10aHistory, 17th Century10aHistory, 18th Century10aHistory, 19th Century10aHistory, Ancient10aHistory, Medieval10aHumans10aleprosy10aMetagenomics10aMycobacterium leprae10aMycobacterium tuberculosis10aTuberculosis1 aDonoghue H00aInsights into ancient leprosy and tuberculosis using metagenomics.  a448-500 v213 a<p>Leprosy and tuberculosis were widespread in the past and remain significant diseases today. Comparison of ancient and modern genomes of Mycobacterium leprae and Mycobacterium tuberculosis gives insight into their evolution and a calibration of the timescale for observed changes. Recently, whole genome sequencing has revealed genotypes and mixed-strain infections.</p>  a1878-4380