02101nas a2200373   4500000000100000008004100001260001300042653001000055653001100065653002300076653001100099653001500110653001100125653001900136653001200155653000900167653001600176653003600192100001300228700001400241700001200255700001300267700001500280700001500295700001100310700002500321700001300346245008500359856007300444300001300517490000700530520117600537022001401713       2013                            d  c2013 Oct10aAdult10aBrazil10aDisease resistance10aFemale10aHaplotypes10aHumans10aInterleukin-1010aleprosy10aMale10aMiddle Aged10aPolymorphism, Single Nucleotide1 aGarcia P1 aAlencar D1 aPinto P1 aSantos N1 aSalgado CG1 aSortica VA1 aHutz M1 aRibeiro-Dos-Santos A1 aSantos S00aHaplotypes of the IL10 gene as potential protection factors in leprosy patients.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807203/pdf/zcd1599.pdf  a1599-6030 v203 a<p>Leprosy is an infectious disease caused by Mycobacterium leprae characterized by dermatoneurological signs and symptoms that has a large number of new cases worldwide. Several studies have associated interleukin 10 with susceptibility/resistance to several diseases. We investigated haplotypes formed by three single nucleotide polymorphisms (SNPs) located in the IL10 gene (A-1082G, C-819T, and C-592A) in order to better understand the susceptibility to and severity of leprosy in an admixed northern Brazil population, taking into account estimates of interethnic admixture. We observed the genotypes ACC/ACC (P = 0.021, odds ratio [OR] [95% confidence interval (CI)] = 0.290 [0.085 to 0823]) and ACC/GCC (P = 0.003, OR [95% CI] = 0.220 [0.504 to 0.040]) presenting significant results for protection against leprosy development, framed in the profiles of low and medium interleukin production, respectively. Therefore, we suggest that genotypes A-1082G, C-819T, and C-592A formed by interleukin-10 polymorphisms are closely related to protection of the leprosy development in an admixed northern Brazil population, in particular ACC/ACC and ACC/GCC genotypes. </p>  a1556-679X