01386nas a2200241   4500000000100000008004100001260001700042653001200059653001500071653001400086653001100100653002100111653001200132653002500144100001300169700001400182245007400196856005600270300001100326490000700337520078600344022001401130       2013                            d  c2013 Nov-Dec10aAnimals10aBiomarkers10aCytokines10aHumans10aImmunity, Innate10aleprosy10aMycobacterium leprae1 aPandhi D1 aChhabra N00aNew insights in the pathogenesis of type 1 and type 2 lepra reaction.  uhttp://www.ijdvl.com/text.asp?2013/79/6/739/120719   a739-490 v793 a<p>In the current scenario of leprosy elimination, lepra reactions (LRs) remain a major persistent problem. Type 1 LR (T1LR) and type 2 LR (T2LR) are the major causes of nerve damage and permanent disabilities. The immunopathogenesis of LR have recently become an important field of research, since it may provide the relevant targets for the early detection and control of these episodes. Presently, there are no uniformly acceptable laboratory markers for LR. Genetic and serum markers in human host may predict susceptibility to reactions as well as progression of nerve damage in leprosy. Therefore, a deeper understanding of the molecular mechanisms involved in LR may provide a rational strategy for early diagnosis and prevention of the catastrophic consequences of LR. </p>  a0973-3922