01752nas a2200169   4500000000100000008004100001653001700042653002300059653001200082653002000094100001500114700001600129700001600145245007600161490000600237520133900243       2013                            d10aSaudi Arabia10aMulti drug therapy10aleprosy10aAdverse effects1 aAl-Sieni A1 aAl-Layati W1 aAl-Abbasi F00aTemporal adverse effects in leprosy Saudi patients receiving multi drug0 v43 aBackground/Purpose: Leprosy or Hansen’s disease is an infectious disease that yet represents major socioeconomic
burden to humanity. It results in permanent physical disabilities besides disgraceful social perception to
patients. Multi Drug Therapy (MDT) treatment protocol is a combinatorial anti microbial treatments which has been
approved by the WHO as the best treatment option for Hansen’s disease. Side effects to MDT protocol are the main
limiting obstacle for the treatment course completion that might differ from population to another.
Methods: Herein, we are assessing the temporal hematological and biochemical markers of side effects in Saudi
leprosy patients treated with MDT protocol for one year.
Results: Hematological assessment revealed progressive temporal but mild decline in all the examined parameters
(RBC, PCV, Hb, MCH and MCHC) in males and females patients treated with MDT compared to control group.
Biochemical assessment for MDT treated leprosy Saudi patients presented mild progressive temporal hepato-renal
complications. Patients were fully recovered from all hemato-biochemical adverse effects after 6 months of the MDT
treatment completion.
Conclusion: MDT was well tolerated in Saudi leprosy patients with mild to moderate temporal hematological and
biochemical adverse reactions.