01334nas a2200217 4500000000100000008004100001653001700042653001200059653001000071653001100081100001400092700001300106700001600119700001900135700002200154245006800176856007100244050001400315520077300329022001401102 2015 d10aPolymorphism10aleprosy10aErbB210aBrazil1 aMachado P1 aRêgo JL1 aOliveira JM1 aLima Santana N1 aCastellucci CLéa00aThe role of ERBB2 gene polymorphisms in leprosy susceptibility. uhttp://www.sciencedirect.com/science/article/pii/S1413867015000306 aREGO 20153 a

Mycobacterium leprae infects skin and peripheral nerves causing deformities and disability. The M. leprae bacterium binds to ErbB2 on the Schwann cell surface causing demyelination and favoring spread of the bacilli and causing nerve injury. Polymorphisms at the ERBB2 gene were previously investigated as genetic risk factors for leprosy in two Brazilian populations but with inconsistent results. Herein we extend the analysis of ERBB2 variants to a third geographically distinct population in Brazil. Our results show that there is no association between the genotyped SNPs and the disease (p>0.05) in this population. A gene set or pathway analysis under the genomic region of ERBB2 will be necessary to clarify its regulation under M. leprae stimulus.

 a1678-4391