01474nas a2200301   4500000000100000008004100001260001600042653000900058653002500067653002700092653001200119100001200131700001300143700001200156700001000168700001200178700001300190700002100203700001200224700001500236700001600251700001500267700001100282245008500293856008600378520069400464022001401158       2014                            d  c2014 Feb 2510aSNPs10aRifampicin-resistant10aMolecular Epidemiology10aleprosy1 aSingh P1 aBenjak A1 aCarat S1 aKai M1 aBusso P1 aAvanzi C1 aPaniz-Mondolfi A1 aPeter C1 aHarshman K1 aRougemont J1 aMatsuoka M1 aCole S00aGenome-wide re-sequencing of multi-drug resistant Mycobacterium leprae Airaku-3.  uhttp://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(14)65395-7/pdf3 a<p>Genotyping and molecular characterization of drug resistance mechanisms in Mycobacterium leprae enables disease transmission and drug resistance trends to be monitored. In the present study, we performed genome-wide analysis of Airaku-3, a multidrug resistant strain with an unknown mechanism of resistance to rifampicin. We identified 12 unique non-synonymous single-nucleotide polymorphisms (SNPs) including two in the transporter-encoding ctpC and ctpI genes. In addition, two SNPs were found that improve the resolution of SNP-based genotyping, particularly for Venezuelan and South-East Asian strains of M. leprae. This article is protected by copyright. All rights reserved.</p>
  a1469-0691