02403nas a2200349 4500000000100000008004100001260001300042653001000055653002400065653001100089653001100100653003000111653001200141653000900153653001600162653003900178653001100217653002500228653002700253653002200280100001500302700002100317700001200338700001400350700001300364700001700377245012800394300001100522490000700533520149900540022001402039 2014 d c2014 Jan10aAdult10aDouble-Blind Method10aFemale10aHumans10aInjections, Intralesional10aleprosy10aMale10aMiddle Aged10aPeripheral Nervous System Diseases10aPlasma10aPlatelet-rich plasma10aSensory Receptor Cells10aTreatment Outcome1 aAnjayani S1 aWirohadidjojo YW1 aAdam AM1 aSuwandi D1 aSeweng A1 aAmiruddin MD00aSensory improvement of leprosy peripheral neuropathy in patients treated with perineural injection of platelet-rich plasma. a109-130 v533 a
BACKGROUND: Leprosy (Hansen's disease) is a chronic granulomatous infection caused by Mycobacterium leprae with peripheral neuropathy as cutaneous and neurological manifestations. Peripheral nerve regeneration may be stimulated by vascular endothelial growth factor and other growth factors (GFs) that have important roles in extracellular matrix regeneration. All of those GFs can be found in platelet-rich plasma (PRP) preparation. The effect of PRP injection in leprosy peripheral neuropathy has never been reported.
MATERIALS AND METHODS: A double-blind, randomized, control clinical trial was conducted among 60 patients with leprosy peripheral neuropathy. They were randomized to receive either a 1-ml injection of PRP as treatment or a 1-ml injection of platelet-poor plasma (PPP) as control. Skin sensibilities were measured by two-point discrimination test (TPDT) and visual analog scale (VAS), which were taken before and two weeks after treatment.
RESULTS: Perineural injection of PRP was shown to be significantly more effective than PPP (P < 0.05) either in VAS or TPDT measurements. In both groups, the patients had a tingling sensation at the time of injection that disappeared shortly after.
CONCLUSION: This study shows that perineural PRP injection could promote improvement of peripheral neuropathy sensibility in patients with leprosy. More research is needed to better determine the effects of PRP in nerve regeneration.
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