02486nas a2200433   4500000000100000008004100001260001300042653003100055653000900086653001100095653002800106653001100134653002900145653002300174653001100197653001200208653001800220653000900238653001800247653001500265653003700280653002000317653003100337653002600368653003100394653003000425100001800455700001500473700001400488700001200502700001400514700001500528245011300543300001000656490000700666050002000673520134500693022001402038       2014                            d  c2014 Apr10aActivities of Daily Living10aAged10aBrazil10aCross-Sectional Studies10aFemale10aHealth Status Indicators10aHome Care Services10aHumans10aleprosy10aLinear Models10aMale10aMental Health10aPerception10aPsychiatric Status Rating Scales10aQuality of Life10aReproducibility of Results10aSocioeconomic Factors10aSurveys and Questionnaires10aWorld Health Organization1 aChaitanya V S1 aJadhav R S1 aLavania M1 aSingh M1 aValluri V1 aSengupta U00aInterleukin-17F single-nucleotide polymorphism (7488T>C) and its association with susceptibility to leprosy.  a131-70 v41  aCHAITANYA 2013B3 aThe objective of this study was to investigate the association, if any, between the interleukin-17F (7488T>C) (rs763780) polymorphism and susceptibility to leprosy and to elucidate the relationship between IL-17F genotypes and clinical profile of the disease. DNA was extracted from the peripheral venous blood of leprosy cases (n = 140), which were classified as per WHO classification into paucibacillary (PB) (n = 53) and multibacillary (MB) (n = 87) categories and healthy controls (n = 84) without any signs and symptoms of leprosy. The IL-17F (7488 T/C) polymorphism was genotyped using amplification refractory mutation system - polymerase chain reaction (Allele-specific amplification). In both PB and MB categories of leprosy cases, the homozygous TT genotype frequency was significantly higher than that of the healthy controls (78.70% vs. 29.76%, P < 0.05). The heterozygous TC genotype was higher in the controls than in the leprosy cases (57.14% vs. 17.68%, P < 0.05). TT genotype was more associated with the type 1 reactional states and tuberculoid/borderline tuberculoid groups in leprosy than the TC genotype. This study reveals that the IL-17F (7488T>C) single-nucleotide polymorphism is associated with susceptibility to leprosy and polymorphism confers decrease in risk of contracting leprosy in the north Indian cohort.  a1744-313X