01960nas a2200313   4500000000100000008004100001653002600042653001300068653003000081653003300111653001200144653002500156653001800181653001900199653002100218653002100239653001100260653004400271653002000315100001600335700001500351245007000366856006800436300001200504490000700516050001800523520109100541022001401632       2014                            d10aSkin smear microscopy10aSerology10apolymerase chain reaction10aMitsuda intradermal reaction10aleprosy10aImmunohistochemistry10aImaging tests10aHistopathology10aElectromyography10aChemoprophylaxis10aBrazil10abacillus Calmette-Guérin (BCG) vaccine10aand blood tests1 aLastória J1 aAbreu MAMM00aLeprosy: a review of laboratory and therapeutic aspects - Part 2.  uhttp://www.scielo.br/pdf/abd/v89n3/0365-0596-abd-89-03-0389.pdf  a389-4010 v89  aLASTORIA 20143 a<p>Leprosy is a chronic infectious condition caused by Mycobacterium leprae(M. leprae). It is endemic in many regions of the world and a public health problem in Brazil. Additionally, it presents a wide spectrum of clinical manifestations, which are dependent on the interaction between M. leprae and host, and are related to the degree of immunity to the bacillus. The diagnosis of this disease is a clinical one. However, in some situations laboratory exams are necessary to confirm the diagnosis of leprosy or classify its clinical form. This article aims to update dermatologists on leprosy, through a review of complementary laboratory techniques that can be employed for the diagnosis of leprosy, including Mitsuda intradermal reaction, skin smear microscopy, histopathology, serology, immunohistochemistry, polymerase chain reaction, imaging tests, electromyography, and blood tests. It also aims to explain standard multidrug therapy regimens, the treatment of reactions and resistant cases, immunotherapy with bacillus Calmette-Guérin (BCG) vaccine and chemoprophylaxis.</p>
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