00991nas a2200133   4500000000100000008004100001100001300042700001200055245010000067300001400167490000700181520065600188022001300844       2014                            d1 aSavage J1 aLevis W00aThe utility of QuantiFERON-TB Gold assay in patients with leprosy: A possible measure of anergy  a996 - 9970 v713 a<p>We recently reported a tuberculosis-negative patient with leprosy, who displayed a giant purified protein derivative (PPD) reaction and had a positive QuantiFERON-TB Gold (QTF; Cellestis, Valencia, CA) test result.<sup>1</sup> Concurrently, work was published showing <em>Mycobacterium tuberculosis</em> antigens, early secretory antigenic target (ESAT)-6 kd and culture filtrate protein (CFP)-10 kd, are cross-reactive with <em>M&nbsp;leprae</em> and can lead to false-positive QTF results.<sup>2</sup> This supports the notion that QTF assays cannot reliably measure, in patients with leprosy, latent infection with <em>M tuberculosis</em>.</p>
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