02026nas a2200241   4500000000100000008004100001100002200042700002100064700001500085700002100100700001800121700002200139700001500161700002000176700002000196700002300216245013300239856007900372300001100451490000900462520129900471022001401770       2014                            d1 aEscamilla-Tilch M1 aEstrada-Garcia I1 aGranados J1 aArenas-Guzmán R1 aRamos-Payan R1 aPérez-Suárez TG1 aSalazar MI1 aPérez-Lucas RL1 aEstrada-Parra S1 aTorres-Carrillo NM00aLack of Association of the Polymorphisms IL-17A (-197G/A) and IL-17F (+7488A/G) with Multibacillary Leprosy in Mexican Patients.  uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241254/pdf/IJG2014-920491.pdf  a9204910 v20143 a<p>Background. Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae; it has been determined that genetic factors of the host play an important role in the disease susceptibility. Thus, in this case-control study, we evaluated the possible association between the IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs and susceptibility to leprosy disease in Mexican population. Methods. Seventy-five leprosy patients and sixty-nine control subjects were included. Both SNPs were genotyped with the polymerase chain reaction-restriction fragment length polymorphism technique. Results. We found nonsignificant differences in genotype and allele frequencies related to IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs in MB as well as subclinical forms of leprosy disease versus healthy individuals. Conclusions. Since the sample size is not large enough, it is difficult to sustain an association of susceptibility to leprosy with genotypes or allele frequencies of IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780), suggesting that IL-17 polymorphisms have no significant role in the genetic susceptibility to development of this disease in the Mexican Mestizo population.</p>
  a2314-436X