01907nas a2200241   4500000000100000008004100001653001700042653002600059653001900085653002600104653001300130653001200143100001200155700001300167700001600180700001400196700001300210700001300223245008700236300001000323520131800333022001401651       2015                            d10aSkin healing10aCutaneous nerve fibre10aNeuromediators10aPeripheral neuropathy10aDiabetes10aleprosy1 aBetty L1 aAurore D1 aDorothée G1 aLaurent M1 aClaire D1 aAlexis D00aSkin innervation: important roles during normal and pathological cutaneous repair.  a116103 a<p>The skin is a highly sensitive organ. It is densely innervated with different types of sensory nerve endings, which discriminate between pain, temperature and touch. Autonomic nerve fibres which completely derive from sympathetic (cholinergic) neurons are also present. During all the phases of skin wound healing (inflammatory, proliferative and remodelling phases), neuromediators are involved. Several clinical observations indicate that damage to the peripheral nervous system influences wound healing, resulting in chronic wounds within the affected area. Patients with cutaneous sensory defects due to lepromatous leprosy, spinal cord injury and diabetic neuropathy develop ulcers that fail to heal. In addition, numerous experimental observations suggest that neurogenic stimuli profoundly affect wound repair after injury and that delayed wound healing is observed in animal models after surgical resection of cutaneous nerves. All these observations clearly suggest that innervation and neuromediators play a major role in wound healing. Interactions between neuromediators and different skin cells are certainly crucial in the healing process and ultimately the restoration of pain, temperature, and touch perceptions is a major challenge to solve in order to improve patients' quality of life.</p>
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