02455nas a2200217   4500000000100000008004100001653001000042653001700052653001200069653001900081653001400100653002000114100001300134700001500147700001500162245012900177856007400306300000900380490000600389520184200395       2015                            d10aNepal10aMicrobiology10aleprosy10aHistopathology10adiagnosis10aBacillary index1 aTiwari M1 aRanabhat S1 aMaharjan S00aClinico-histopathological correlation of leprosy: A retrospective study of skin biopsy specimens in Chitwan Medical College.  uhttp://www.ijmsrp.com/wp-content/uploads/2015/04/03_Mamata_Tiwari.pdf  a8-110 v23 a<p>Aim of this study was tofind out cases of leprosy diagnosed in skin biopsy specimen and to study clinico-histopathological correlation in diagnosis of leprosy.<br />
Background: Leprosy is caused by Mycobacterium leprae. There are various clinico-pathological forms of leprosy depending on the immune status of the host. Diagnosis of leprosy can &nbsp;be done by clinical, microbiological and histopathological examination. Histopathological examination is considered as important for confirmatory diagnosis, for assessment of regression of the disease in patient under treatment and also for research purposes. Number of skin lesions in patients, Ridley and Jopling (RJ) classification and bacilliary index in histological sample all can be correlated for proper classification and treatment of leprosy cases.<br />
Materials and Methods: This retrospective study included cases of leprosy diagnosed in skin biopsy specimen in the Department of Pathology of Chitwan Medical College from April 2009 to March 2014. Clinical diagnosis was correlated with that of histopathological diagnosis.<br />
Results: In this study, male to female ratio was 1.4:1. Mean age of patients was 32.66 years. Most common lesion was hypopigmented macule (68%). On the basis of RJ scale, maximum cases (41%) were classified as borderline tuberculoid leprosy (BT) and least number (3.7%) as leprosy, and polar lepromatous leprosy. Maximum clinico-histopathological correlation was seen in borderline lepromatous leprosy (87.5%) followed by BT (68.1%). Fite ferraco stain was done in only 27 cases. It was 0-2 in tuberculoid spectrum and &gt;2 in lepromatous spectrum.<br />
Conclusion: Combining clinical, histopathological and microbiological diagnosis of leprosy is important for proper treatment of the patient and prevention of complications.</p>