01634nas a2200193   4500000000100000008004100001100001600042700002000058700001300078700001200091700001400103700001700117245009100134856010600225300001100331490000700342520107700349022001401426       2015                            d1 aMonteiro LD1 aMartins-Melo FR1 aBrito AL1 aLima MS1 aAlencar C1 aHeukelbach J00a[Leprosy trends in Tocantins, a hyperendemic State in the North of Brazil, 2001-2012].  uhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2015000500009&lng=en&nrm=iso&tlng=en  a971-800 v313 a<p>Leprosy is hyperendemic in the State of Tocantins, Brazil. The aim of the study was to analyze trends in leprosy indicators in Tocantins from 2001 to 2012, based on analysis of data from the Information System for Notifiable Diseases (SINAN), including incident cases living in Tocantins. The study calculated leprosy indicators and analyzed time trends using polynomial regression. There was a significant downward trend in overall case detection (R2 = 0.40; p &lt; 0.05) and proportion of paucibacillary cases (R2 = 0.81). Detection rates remained stable in individuals &lt; 15 years (R2 = 0.48; p &gt; 0.05) and cases with grade 2 physical disability (R2 = 0.37; p &gt; 0.05), as did the proportion of grade 2 cases (R2 = 0.49; p &gt; 0.05). There were significant increases in the proportions of cases with grade 1 disability (R2 = 0.82; p &lt; 0.05) and multibacillary cases (R2 = 0.81; p &lt; 0.05). Tocantins has regions with high transmission and late diagnosis of leprosy, indicating heterogeneous dissemination of the disease in the time trend analysis.</p>
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