01750nas a2200253   4500000000100000008004100001653001400042653002500056100001200081700001300093700001300106700001700119700001300136700001200149700002500161700001500186700001700201245008100218300001700299490000800316050001400324520114400338022001401482       2015                            d10aSelectins10aImmunohistochemistry1 aSouza J1 aSousa JR1 aHirai KE1 aMota Silva L1 aFuzii HT1 aDias LB1 aOliveira Carneiro FR1 aAarão TLS1 aQuaresma JAS00aE-selectin and P-selectin expression in endothelium of leprosy skin lesions.  ap. 227 - 2310 v149  aSOUZA20153 a<p>Leprosy is an infectious-contagious disease whose clinical evolution depends on the immune response pattern of the host. Adhesion molecules and leukocyte migration from blood to tissue are of the utmost importance for the recognition and elimination of infectious pathogens. Selectins are transmembrane glycoproteins that share a similar structural organization and can be divided into three types according to their site of expression. The biopsies were cut into 5μm thick sections and submitted to immunohistochemistry using antibodies against E-selectin and P-selectin. The number of E-selectin-positive cells was significantly higher in the tuberculoid form than in the lepromatous form. The immunostaining pattern of P-selectin differed from that of E-selectin. Analysis showed a larger number of endothelial cells expressing CD62P in the lepromatous form compared to the tuberculoid form. The presence of these adhesins in the endothelium contributing to or impairing the recruitment of immune cells to inflamed tissue and consequently influences the pattern of immune response and the clinical presentation of the disease.</p>
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