01035nas a2200181   4500000000100000008004100001100001400042700001200056700001500068700001200083700001200095700001200107700001500119700001100134245011900145520057500264022001400839       2015                            d1 aLavania M1 aNigam A1 aTurankar R1 aSingh I1 aGupta P1 aKumar S1 aSengupta U1 aJohn A00aEmergence of primary drug resistance to rifampicin in Mycobacterium leprae strains from leprosy patients in India.3 a<p>Rifampicin (RIF) is an important first-line antibiotic for the treatment of mycobacterial infections including leprosy. It is a bactericidal antibiotic that inhibits the bacterial RNA polymerase. Rifampicin resistance is therefore a valuable surrogate marker for drug resistance in leprosy. The aim of the study was to identify mutation in the rpoB (Rifampicin), folP (Dapsone) and gyrA (Ofloxacin) genes by molecular methods in leprosy patients from the TLM hospitals in India. Among 215 cases, we detected seven cases of primary drug resistance to rifampicin.</p>
  a1469-0691