01776nas a2200253   4500000000100000008004100001260001300042653002000055653002800075653003500103653001100138653001500149653002800164653001200192100001600204700001900220700001500239700001200254245019300266300001100459490000700470520103100477022001401508       1975                            d  c1975 Jun10aCreatine Kinase10aDiagnosis, Differential10aFructose-Bisphosphate Aldolase10aHumans10aIsoenzymes10aL-Lactate Dehydrogenase10aleprosy1 aAgarwal D P1 aSrivastava L M1 aGoedde H W1 aRohde R00aBiochemical, immunological and genetic studies in leprosy. I. Changes in serum lactate dehydrogenase isoenzymes, creatine phosphokinase and aldolase activity in different forms of leprosy.  a207-110 v263 a<p>Serum lactate dehydrogenase isoenzymes, creatine phosphokinase and aldolase activity were determined in healthy control subjects and in lepromatous and tuberculoid leprosy patients from Ethiopia. Sera from lepromatous patients showed a higher total LDH activity compared with control subject. The values for tuberculoid leprosy patients were similar to those of controls. Sera from normal healthy controls showed a higher proportion of LDH-H form (72%) while lepromatous leprosy patient's sera exhibited a higher proportion of LDH-M form (55%). Tuberculoid leprosy patients showed a pattern similar to that of healthy controls. A possible significance of these observations is discussed. No significant variations were observed in fructose-1,6-diphosphate aldolase activity within the different types of disease and controls. Although creatine phosphokinase levels in different types of leprosy decreased significantly from those of normal healthy, it falls within the reported variation of the activity in normal sera.</p>  a0303-4208