01648nas a2200205   4500000000100000008004100001653002600042653002000068653001400088100001500102700001300117700001500130700001300145700001700158245008700175300001200262490000700274520114700281022001401428       2016                            d10aQuantitative analysis10aImmunopathology10aCytokines1 aAarão TLS1 aSousa JR1 aBotelho BS1 aFuzii HT1 aQuaresma JAS00aCorrelation between nerve growth factor and tissue expression of IL-17 in leprosy.  a64–680 v903 a<p>Editor's Abstract:</p>

<p>Leprosy is a serious public health problem in peripheral and developing countries. Leprosy is a chronic infectious-contagious disease caused by the intracellular, bacillus Mycobacterium leprae, which causes tissue damage and demyelination of peripheral nerves. Recent studies have demonstrated the participation of new subtype's cytokines profile in the inflammatory response of leprosy. Since nerve functions are affected by inflammatory response during the course of leprosy, changes in the production of NGF and its receptor (NGF R) may be directly associated with disability and sensory loss. Skin biopsies were collected and submitted to immunohistochemistry using specific antibodies to IL-17, NGF and NGF R. Quantitative analysis of NGF, NGFR and IL-17 immunostaining showed a significant difference between the clinical forms, with higher expression of NGF and NGFR in lepromatous leprosy and IL-17 in tuberculoid leprosy. The present study showed that IL-17, in addition to stimulating an inflammatory response, negatively regulates the action of NGF and NGF R in the polar forms of the disease.</p>
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