01477nas a2200241   4500000000100000008004100001653001500042653001800057653001200075653001000087653003200097653002200129100001500151700001300166700002400179700001400203700001300217700001400230700001300244245008000257520088400337022001401221       2016                            d10ars1090528410aPolymorphisms10aleprosy10aGATA310aGATA-3 transcription factor10aAssociation study1 aMedeiros P1 aSilva WL1 aOliveira Gimenez BB1 aValezi KB1 aMoraes M1 aSouza VNB1 aLatini A00aThe GATA3 gene is involved in leprosy susceptibility in Brazilian patients.3 a<p>Leprosy outcome is a complex trait and the host-pathogen-environment interaction defines the emergence of the disease. Host genetic risk factors have been successfully associated to leprosy. The 10p13 chromosomal region was linked to leprosy in familial studies and GATA3 gene is a strong candidate to be part of this association. Here, we tested tag single nucleotide polymorphisms at GATA3 in two case-control samples from Brazil comprising a total of 1633 individuals using stepwise strategy. The A allele of rs10905284 marker was associated with leprosy resistance. Then, a functional analysis was conducted and showed that individuals carrying AA genotype express higher levels of GATA-3 protein in lymphocytes. So, we confirmed that the rs10905284 is a locus associated to leprosy and influences the levels of this transcription factor in the Brazilian population.</p>
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