01799nas a2200241   4500000000100000008004100001653001500042653001800057653001200075653002000087653002000107100001300127700001400140700001500154700001200169700002500181700001300206700001700219245007900236050001700315520121100332022001401543       2016                            d10aMacrophage10aM2 macrophage10aleprosy10aImmunopathology10aClinical aspect1 aSousa JR1 aSousa RPM1 aAarão TLS1 aDias LB1 aOliveira Carneiro FR1 aFuzii HT1 aQuaresma JAS00aIn situ expression of M2 macrophage subpopulation in leprosy skin lesions.  aDESOUSA 20163 a<p>The clinical manifestations of the leprosy depend of host immune response and the macrophages are the primary cells involved in this process. M1 and M2 cells exhibited distinct morphology, distinct surface marker profiles, as well as different cytokine and chemokine secretion. Macrophages express receptors such as CD163, CD68, CD206, and costimulatory molecules such as CD80 and CD86, and cytokines that trigger a suppressive or inflammatory response. Thirty-three untreated patients were selected, 17 patients had the tuberculoid leprosy (TT) and 16 had the lepromatous leprosy (LL). We performed immunohistochemistry to detect IL-13, IL-10, TGF-β, FGF-β, CD163, CD68, arginase 1. M2 macrophages showed significant differences between the groups studied with increase in the expression of costimulatory molecules (CD68 and CD163), arginase 1 and cytokines (IL-10, IL-13, TGF-β and FGF-b) in the LL form. Response of M2 macrophages emerge as an alternative for a better understanding of the innate immunity in the polar forms of leprosy, highlighting the role of cytokines, arginase 1 and costimulatory molecules in the repair and suppressive responses in the lepromatous form of the disease.</p>
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