01870nas a2200253   4500000000100000008004100001653002300042653001200065653001500077653001700092653002600109653001100135100001300146700001600159700001900175700001700194700001400211245013600225856007800361300001200439490000700451520114400458022001401602       2016                            d10aNeglected Diseases10aleprosy10aIncidence.10aEpidemiology10aCommunicable Diseases10aBrazil1 aBrito AL1 aMonteiro LD1 aNovaes Ramos A1 aHeukelbach J1 aAlencar C00aTemporal trends of leprosy in a Brazilian state capital in Northeast Brazil: epidemiology and analysis by joinpoints, 2001 to 2012.  uhttp://www.scielo.br/pdf/rbepid/v19n1/en_1980-5497-rbepid-19-01-00194.pdf  a194-2040 v193 a<p>The objective of this study was to characterize epidemiological and temporal trends of leprosy in the city of Fortaleza, Ceará, Brazil, from 2001 to 2012. A total of 9,658 new cases were reported. Their temporal trend was analyzed by the jointpoint regression model. The overall detection rate showed a declining trend, with annual percent change (APC) of -4.0 and 95% confidence interval (95%CI) -5.6 - -2.3. The detection rate in children under 15 years of age (APC = -1.4; 95%CI -5.4 - 2.8) and the detection rate of disability grade 2 (APC = -0.8; 95%CI -4.5 - 3.1) were stable. The proportion of female patients was descending (APC = -1,5; 95%CI -2.3 - -0.8). The proportion of multibacillary cases from 2005 to 2012 (APC = 1.4; 95%CI 0.6 - 2.3) and among them, lepromatous cases from 2004 to 2012 (APC = 6.0; 95%CI 3.4 - 8.6) were increasing. There was stability in the proportion of cases with grade 1 (APC = 1.4; 95%CI -0.9 - 3.7) and grade 2 disability (APC = 3.7; 95%CI -0.1 - 7.8). Despite the trend towards a reduction in detection, the disease transmission persists in the city. The data also suggest late diagnosis.</p>
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