01824nas a2200349   4500000000100000008004100001260001300042653001500055653001000070653000900080653002500089653001100114653001900125653002400144653002800168653002400196653001100220653001200231653000900243653001600252100001200268700001400280700001300294700001400307700001400321700001400335245011100349300001000460490000700470520098300477022001401460       2001                            d  c2001 Jul10aAdolescent10aAdult10aAged10aCase-Control Studies10aFemale10aGastric Mucosa10aGastritis, Atrophic10aHelicobacter Infections10aHelicobacter pylori10aHumans10aleprosy10aMale10aMiddle Aged1 aMisra V1 aMisra S P1 aHatwal D1 aDwivedi M1 aSingh K G1 aBajaj A K00aHelicobacter pylori and associated histopathological changes in gastric biopsies of patients with leprosy.  a271-50 v443 a<p>Two antral biopsies each from 104 patients of leprosy and 100 controls were studied to find out the prevalence of H. pylori and associated histopathological changes. Sections were stained with hematoxylene and eosin, AB/PAS (Ph 2.5) and Loeffler's methylene blue stains. Infection by H. pylori, inflammation and atrophy were found to be significantly more in leprosy patients as compared to controls (p < 0.01, < 0.005 and < 0.02 respectively). On comparing the histopathological changes in various subgroups of leprosy, H. pylori, inflammation and activity showed a statistically decreasing trend from tuberculoid to lepromatous subgroups (p < 0.05, < 0.001, < 0.01 respectively). Atrophy showed a significant increasing trend from tuberculoid to lepromatous group (< 0.001), it is concluded that despite a low prevalence of H. pylori and associated gastritis in patients with lepromatous leprosy, gastric epithelial damage is more marked due to altered immune response.</p>  a0377-4929