02700nas a2200265   4500000000100000008004100001653001700042653001400059653001500073653001200088653004700100653001000147653001400157100001300171700001300184700001400197700001400211700001300225245013300238856009300371300001100464490000700475520193800482022001402420       2016                            d10aTuberculosis10aTreatment10aPrevention10aleprosy10aInfectious Granulomatous Dermatoses (IGDS)10aIndia10adiagnosis1 aGrover S1 aAgale SV1 aD'Costa G1 aValand AG1 aGupta VK00aClinico-histopathological spectrum of infectious granulomatous dermatoses in Western India - A representative study from Mumbai.  uhttp://www.jcdr.net/articles/PDF/7568/16459_CE(Ra1)_F(GH)_PF1(SSAK)_PFA(AK)_PF2(PAG).pdf  aEC10-40 v103 a<p><strong>INTRODUCTION: </strong>Infectious Granulomatous Dermatoses (IGDS) have various aetiological factors with a considerable overlap in the histopathological and clinical features, thus posing a diagnostic dilemma for dermatologists and pathologists.</p>

<p><strong>AIM: </strong>We aimed at determining the histopathological profile of IGDS correlating it with clinical features with an attempt to find the aetiology.</p>

<p><strong>MATERIALS AND METHODS: </strong>In a cross-sectional study conducted in a tertiary referral center of Mumbai over two years, out of 1872 skin biopsies received, 239 histopathologically diagnosed cases of IGDS were studied for histopathological features of granuloma. A clinico-histopathological correlation was attempted. Chi-square test was used for comparison of proportions of different groups.</p>

<p><strong>RESULTS: </strong>Leprosy (211 cases) and tuberculosis (28 cases) were the commonest histopathologically diagnosed IGDS. Leprosy spectrum included BT (30.33% cases), followed by TT (21.32%), BL and LL and 21.79% cases of lepra reactions. Skin TB biopsies on histopathology showed lupus vulgaris (53.85% cases), scrofuloderma (15.38%), TBVC and papulonecrotic tuberculid (11.54% each). In leprosy maximum clinico-pathological agreement was seen at tuberculoid pole (TT 72.7% and BT 56.6%). Among tuberculosis cases, scrofuloderma (100%) and lupus vulgaris (53.8%) showed maximum agreement.</p>

<p><strong>CONCLUSION: </strong>Leprosy and skin TB are the commonest IGDS in Mumbai region though difficult to diagnose and subcategorize with certainty during initial stages. Histopathology plays the important role to elucidate the dilemma. This being a single center study, more such studies with a larger sample size are recommended to get more elaborate data and regional prevalence of these IGDS for a better overall approach to prevention, treatment and control.</p>
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