01641nas a2200181   4500000000100000008004100001653001700042653001700059653001200076653002100088100001400109245012400123856005100247300001100298490000700309520112900316022001401445       2016                            d10aPrednisolone10aMethotrexate10aleprosy10aChronic neuritis1 aHossain D00aManagement of chronic neuritis with a combination regimen of lower doses prednisolone and methotrexate: a brief report.  uhttps://leprosyreview.org/article/87/1/11-8121  a118-210 v873 a<p><strong>INTRODUCTION: </strong>Recommended fixed duration prednisolone regimen was not found effective in the treatment of chronic neuritis. Alternate effective treatment was being sought to reduce the deformity in the field of leprosy.</p>

<p><strong>OBJECTIVE: </strong>We wished to see whether a prolonged course of prednisolone and methotrexate could be of any help for them.</p>

<p><strong>METHODOLOGY: </strong>In 2012-2014, an open pilot clinical study was undertaken where three chronic neuritic patients were treated with lower doses prednisolone and methotrexate for 12 months and a follow up period was delivered for 12 months. The study was undertaken in one of the outdoor clinics of the university.</p>

<p><strong>RESULTS: </strong>Complete and permanent remission of neuritis was achieved with appreciable functional recovery. Few mild self-limiting side-effects from prednisolone were observed and there was no side-effects from methotrexate.</p>

<p><strong>CONCLUSION: </strong>Prolonged course of prednisolone and methotrexate was found safe and effective in treating chronic neuritis.</p>
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