02460nas a2200337   4500000000100000008004100001653001300042653003000055653001200085653001400097653001700111100001700128700001400145700001200159700001300171700001500184700001200199700001700211700001300228700001300241700001200254700001500266700002100281700001200302245020500314856009000519300001300609490000700622520147900629022001402108       2016                            d10aSerotype10aResource Limited Settings10aendemic10adiagnosis10aDengue virus1 aLe Gonidec E1 aMaquart M1 aDuron S1 aSavini H1 aCazajous G1 aVidal P1 aChenilleau M1 aRoseau J1 aBenois A1 aDehan C1 aKugelman J1 aLeparc-Goffart I1 aVédy S00aClinical survey of dengue virus circulation in the Republic of Djibouti between 2011 and 2014 identifies serotype 3 epidemic and recommends clinical diagnosis guidelines for resource limited settings.  uhttp://journals.plos.org/plosntds/article/asset?id=10.1371%2Fjournal.pntd.0004755.PDF  ae00047550 v103 a<p>Dengue virus is endemic globally, throughout tropical and sub-tropical regions. While the number of epidemics due to the four DENV serotypes is pronounced in East Africa, the total number of cases reported in Africa (16 million infections) remained at low levels compared to Asia (70 million infections). The French Armed forces Health Service provides epidemiological surveillance support in the Republic of Djibouti through the Bouffard Military hospital. Between 2011 and 2014, clinical and biological data of suspected dengue syndromes were collected at the Bouffard Military hospital and analyzed to improve Dengue clinical diagnosis and evaluate its circulation in East Africa. Examining samples from patients that presented one or more Dengue-like symptoms the study evidenced 128 Dengue cases among 354 suspected cases (36.2% of the non-malarial Dengue-like syndromes). It also demonstrated the circulation of serotypes 1 and 2 and reports the first epidemic of serotype 3 infections in Djibouti which was found in all of the hospitalized patients in this study. Based on these results we have determined that screening for Malaria and the presence of the arthralgia, gastro-intestinal symptoms and lymphopenia &lt; 1,000cell/ mm3 allows for negative predictive value and specificity of diagnosis in isolated areas superior to 80% up to day 6. This study also provides evidence for an epidemic of Dengue virus serotype 3 previously not detected in Djibouti.</p>
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