01324nas a2200337   4500000000100000008004100001260001300042653001200055653002900067653001200096653002200108653002700130653002300157653001200180653001000192653000900202653002100211653001600232653001500248653001500263653001300278653001700291100001500308700001700323700001800340245015500358300001100513490000800524520044000532022001400972       2001                            d  c2001 Nov10aAnimals10aAnti-Inflammatory Agents10aDapsone10aDrug Combinations10aHorseradish Peroxidase10aLeprostatic Agents10aleprosy10aLiver10aMice10aMice, Inbred CBA10aNeutrophils10aPeroxidase10aPhagocytes10aRifampin10aTime Factors1 aMaslov A K1 aLuzhnova S A1 aKalyanina O V00aEffect of peroxidase in complex with basic antileprosy drugs on liver, blood, and functional activity of phagocytes in mice with experimental leprosy.  a1084-60 v1323 a<p>Therapeutic effect of lyophilized horseradish peroxidase in complex with the basic antileprosy drugs diaminodiphenylsulfone and rifampicin was studied in experimental leprosy. Oral therapy with drug complexes was more effective than monotherapy. Treatment with drug combinations activated myeloperoxidase in blood neutrophil, produced an antiinflammatory effect, stimulated cell immunity, and had no toxic effect on mouse liver.</p>  a0007-4888