01474nas a2200373 4500000000100000008004100001653001300042653001500055653002000070653001100090653001100101653001300112653003300125653002100158653001700179653002600196100001800222700001300240700001600253700000900269700002200278700001100300700001500311700001100326700001500337700001300352700001500365245008500380856006500465300001000530490000700540520053900547022001401086 2004 d10aTrachoma10aOdds Ratio10aLogistic Models10aInfant10aHumans10aEthiopia10aCommunicable Disease Control10aChild, Preschool10aAzithromycin10aAnti-Bacterial Agents1 aChidambaram J1 aMelese M1 aAlemayehu W1 aYi E1 aPrabriputaloong T1 aLee DC1 aCevallos V1 aZhou Z1 aWhitcher J1 aGaynor B1 aLietman TM00aMass antibiotic treatment and community protection in trachoma control programs. uhttp://cid.oxfordjournals.org/content/39/9/e95.full.pdf+html ae95-70 v393 a

Azithromycin is highly effective against trachoma, but the practical difficulties of community-wide distribution often leave many individuals untreated. We demonstrate, after mass azithromycin treatment of a population in Ethiopia, an indirect protective effect that occurred among untreated children who resided in villages in which most individuals had been treated. Similarities with the indirect protection within a treated community (i.e., "herd protection") that has been observed in vaccination programs are discussed.

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