02532nas a2200361   4500000000100000008004100001653001400042653001200056653002700068653001400095653001100109653001700120653001700137100001100154700001400165700001300179700001200192700001500204700001200219700001300231700001600244700001100260700001500271700001200286700001200298700001400310245009400324856006900418300001200487490000800499520164900507022001402156       2016                            d10aTreatment10aNigeria10aMycobacterium ulcerans10adiagnosis10aDelays10aCare-seeking10aBuruli ulcer1 aMeka A1 aChukwu JN1 aNWAFOR C1 aOshi DC1 aMADICHIE N1 aEkeke N1 aAnyim MC1 aAlphonsus C1 aMbah O1 aUzoukwa GC1 aNjoku M1 aNtana K1 aUkwaja KN00aDiagnosis delay and duration of hospitalisation of patients with Buruli ulcer in Nigeria.  uhttp://trstmh.oxfordjournals.org/content/110/9/502.full.pdf+html  a502-5090 v1103 a<p><strong>BACKGROUND: </strong>Delayed diagnosis of Buruli ulcer can worsen clinical presentation of the disease, prolong duration of management, and impose avoidable additional costs on patients and health providers. We investigated the profile, delays in diagnosis, duration of hospitalisation, and associated factors among patients with Buruli ulcer in Nigeria.</p>

<p><strong>METHODS: </strong>This was a prospective cohort study of patients with Buruli ulcer who were identified from a community-based survey. Data on the patients' clinical profile, delays in diagnosis and duration of hospitalisation were prospectively collected.</p>

<p><strong>RESULTS: </strong>Of 145 patients notified, 125 (86.2%) were confirmed by one or more laboratory tests (81.4% by PCR). The median age of the patients was 20 years, 88 (60.7%) were &gt;15years old and 85 (58.6%) were females. In addition, 137 (94.5%) were new cases, 119 (82.1%) presented with ulcers and 110 (75.9%) had lower limb lesions. The mean time delay to diagnosis was 50.6 (±101.9) weeks. The mean duration of hospitalisation was 108 (±60) days. Determinants of time delay to diagnosis were higher disease category (p=0.001) and laboratory confirmation of disease (p=0.02). Determinants of longer hospitalisation were; multiple lesions (p=0.035), and having functional limitation at diagnosis and undertaking surgery (p=0.003).</p>

<p><strong>CONCLUSIONS: </strong>Patients with Buruli ulcer have very long time delays to diagnosis and long hospitalisation during treatment. This calls for early case-finding and improved access to Buruli ulcer services in Nigeria.</p>
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