01099nas a2200241   4500000000100000008004100001653001400042653001700056653002500073653001200098100001400110700000900124700001300133700001300146700001300159700001300172245005700185856009700242300001300339490000700352520048400359022001400843       2017                            d10aTreatment10aNitazoxanide10aMycobacterium leprae10aleprosy1 aBailey MA1 aNa H1 aDuthie M1 aGillis T1 aLahiri R1 aParish T00aNitazoxanide is active against Mycobacterium leprae.  uhttp://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0184107&type=printable  ae01841070 v123 a<p>Nitazoxanide (NTZ) is an anti-parasitic drug that also has activity against bacteria, including Mycobacterium tuberculosis. Our data using both radiorespirometry and live-dead staining in vitro demonstrate that NTZ similarly has bactericidal against M. leprae. Further, gavage of M. leprae-infected mice with NTZ at 25mg/kg provided anti-mycobacterial activity equivalent to rifampicin (RIF) at 10 mg/kg. This suggests that NTZ could be considered for leprosy treatment.</p>
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