Leprosy is a disease, which affects the psycho-social, physical and spiritual well being of the patients with leprosy. The present study is carried out in Agra and Kanpur district, A sample of 200 female leprosy patients have been included, who were registered and taking treatment from the Govt. OPDs, S. N. Medical College, Agra, G.S.V.M. Medial College, Kanpur, N.J.I.L. and OMD ICMR, Agra, PHCs, CHCs and District Hospitals of both the Districts, age group of 18 to 60 years. The objective of the study is to assess the attitude of the females towards the disease in the integrated set up in Agra and Kanpur districts of U.P. It was observed that 62.5% of the females think that leprosy is not a common disease it is a fatal disease. On the other side 38% of them were uncertain about to be healthy after the treatment. Only 40.5% of the patients had hope to be healthy in future after the treatment. Negative attitude towards the disease, curability of the disease, burden themselves in the family and feeling of ashamed (due to self-stigmatization) was found in the present study in the current integrated set up.